Wednesday , August 17 2022

Living probiotics can alter existing intestinal flora and change the immune response



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New research published in International Journal of Pharmaceutics demonstrates the "good" bacteria in the live probiotic SymproveTM can successfully achieve and colonize the intestines, where they continue to change the existing intestinal flora. They are also able to modify the immune response.

Researchers have found that all bacteria in Symprove have survived stomach acid to reach and colonize the intestines. Bacterial activity was observed in this study using a new human intestinal microbial ecosystem simulator (SHIME) and donor bacteria from healthy people. This allows scientists to closely monitor bacteria by in vitro simulation of the human intestine without the need for invasive procedures and measurements.

Bacteria in Symproves have been tested to see if their colonization will help feed intestinal microbes by producing lactate. The microbe has been identified as a disease modifier and an essential part of immunity.

Simon Gaisford, a professor of medicine at University College London, said: "We have been able to show that supplying viable and active bacteria to the intestines affects healthy bacteria in our body in a way we have not seen yet. this effect is maintained week by week.We saw that the addition of Symprove reduced the number of inflammatory markers and increased levels of butyrate.If we can create a healthier microbium healthier, the potential to improve dysbiosis conditions is incredibly exciting. "

Adding Probiotics in Symprove to healthy human donor microbes has altered the proportion of bacterial groups in the intestinal flora, which has resulted in a significant increase in butyrate – short chain fatty acids (SCFA) that are critical to health and well-being.

The addition of Symprove also increased the IL-6 and IL-10 anti-inflammatory cytokines, while reducing IL-8, MCP-1 and CXCL10 inflammatory chemokines associated with inflammatory conditions and viral infections. Data showed that microbiological feeding results in changes in intestinal flora as well as a positive anti-inflammatory and immunomodulatory effect.

Increased abundance of utility bacteria, such as fixicuts and actinobacteria, was also observed after the addition of Symprove bacteria to simulation vessels. The lack of these bacteria in the gut is associated with several medical conditions, including irritable bowel syndrome.

"Given that further research focuses on microbiology and its relationship to general health, the more positive the impact of specialized water-based probiotics will be more widely recognized, indicating that the main contribution of probiotics is their ability to support existing flora within microbiology to help" re- "that," says Barry Smith, founder and chairman of Symprove Limited. "Our research over the last 20 years has sought to understand more about microbiology and the essential role it plays in our overall health. This new research demonstrates the impact of live and active probiotics that can be on the body for the cleansing. It's incredibly exciting that leading academic staff are aware of the impact of microbial feeding. We all have microbiology and in many cases just enough to help with the bacteria that are already in place. "

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