Wednesday , October 5 2022

Scientists are able to regenerate partially amputated frogs TRENDS


A team of scientists from the Tufts University of America succeeded in partially recovering legs for amputated frogs when treated with progesterone using a portable bioreactor attached to the site of injury, as published in the journal Cell Reports.

Conclusions of this investigation can be an example of new cellular stimulation therapies and allow for advances in the treatment of amputation damage in humans.

Some worlds an animal like lizard or crab is able to regenerate in themselves, but this does not happen in the case of the African vein, known under the scientific name Xenopus laevis, and studied in this study.

This type of water frog is able to regenerate the limbs in the early stages of his life, but he loses this ability in adulthood.

The scientists split the frogs into three groups to carry out their experiment, and all went through a portable bioreactor directly to the site of injury left by amputation,

Only frogs from the group received progesterone bioreactor for 24 hours and scientists observed in them, after nine months, partial regeneration of their limbs, which was not observed in the other two groups.

"It caused a very short application of the bioreactor and its useful load (progesterone) month of growth and tissue structure "Michael Levin, one of the study authors and biologist at the Allen Discovery Center at Tufts University in Massachusetts, USA.

Progesterone-treated frogs showed over time some partially regenerated legs, bones, innervation and vascularization, and could swim when they were in the water as if they were not amputated.

Progesterone is a Sex hormone known for its functions at the onset and development of pregnancy, but has also been shown to promote the recovery of nerves, blood vessels and bone tissue.

"We looked at progesterone because it looked promising to support nerve repair and regeneration, but it also modulated the immune response to stimulating treatment and triggering to the growth of blood vessels and bones, "said neurologist Celia Herrero-Rincón, author of the study.

The next step for scientists is to carry out a similar study in mammals and attempt to obtain further evidence that they are The combination of drugs and devices can be a new model attempting therapeutic cocktails that allow induction of regeneration in non-regenerative species.

There are millions of people in the world living with some limbs, lower or higher, amputated and only in the United States is two million in this situation.

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