New York, November 20 (IANS) Scientists have developed a new drug that could block the spread of glioblastoma – the most dangerous form of brain cancer.
The tissues in our body are largely made of fluid. It moves around cells and is essential for normal body function. But in some cases this fluid can do more damage than good.
In people with glioblastoma, this fluid has much higher pressure, causing it to move quickly and forcing cancer cells to spread.
AMD3100, which was already used in clinics, was found effective in stopping unavoidable proliferation of cancer cells, researchers said.
"I'm promising that because the drug that we blocked flow stimulation is currently being used in patients who can clinicians when they consider using increased delivery convection will be combined with this drug," said lead author Chase Cornelison, a postdoctoral researcher the Polytechnic Institute in Virginia and the State University.
The study, published in the journal Scientific Reports, examined the flow of interstitial fluid – which surrounds cells in the body – in the spread of glioma cells.
Composed of circulating cerebrospinal fluid, cellular waste, and blood plasma, the flow of interstitial fluid was previously associated with an increased rate of invasion of glioblastoma or brain tumor cells.
Scientists tested AMD3100 and found they could prevent rapid flow of interstitial fluid in the brain and spread of cancer cells.
They also tested glioblastoma mice to test how a special approach to providing cancer treatment, called convection of increased delivery, caused glioma cells to attack the brain.
"This (glioblastoma) is so deadly and there has been no shift in treatment over the course of several decades. Something has to change … Looking at the flow of fluids, there may be a response we did not see," added Jennifer Munson, an assistant.
rt / ksk / bg