"Coffee consumption seems to be somewhat correlated with a lower risk of developing Alzheimer's and Parkinson's disease," explains Dr. Donald Weaver, co-author of the Krembil Brain Institute. But we wanted to explore why it will happen, what compounds are involved, and how they can affect cognitive aging in relation to age, "Expansion.com said.
Dr. Weaver was assisted by Dr. Rossa Mancini, a medical doctor in medical chemistry, and biologist Yanfei Wang, to investigate three different kinds of coffee: light roast, dark roasted and decaffeinated dark brown.
"Uncooked dark brown and decaffeinated caffeine had the same potential in our initial experimental tests, so we noted from the outset that its protective effect can not be due to caffeine," he explains.
Subsequently, Dr. Mancini identified a group of compounds known as phenylindans that are produced as a result of the process of roasting coffee beans. Phenylindanas are unique because they are the only compound studied in a study that prevents the clustering of both amyloid beta and tau, two protein fragments common in Alzheimer's and Parkinson's disease.
"So the phenylindans are a double inhibitor, it's very interesting and we did not expect it." Dr. Weaver admits. Since coffee roasting produces higher amounts of phenylindane, dark roasting seems to be more protective than light roasting. "It's the first time anyone investigates how phenylalanine interacts with proteins responsible for Alzheimer's and Parkinson's disease," Dr. Mancini.
The next step would be to find out to what extent these compounds are beneficial and whether they have the ability to reach the bloodstream or to cross the blood-brain barrier. "
The fact that it is a natural component compared to a synthetic one is also a great advantage. Weaver. However, it admits that much more research is still needed before it can be translated into possible therapeutic options.
"What this study is doing is to make epidemiological evidence and show that coffee is actually a component that is beneficial for cognitive decline prevention." Interestingly, we suggest that coffee is a cure – definitely not, "he warns.
Source: Banking and business