Tuesday , July 5 2022

ا Urn has a variety of neurological development in microcephaly that are caused by Zika, the study suggests.


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Research done in Salvador (BA) showed that children with microcephaly in the urine that causes the Zika virus have different neurological development when they reach the age of 2 and 3 years. This type of profile can be viewed neurologically through a psychological evaluation, thus allowing for a personalized approach to treatment.

U, Yas, published in the journal PLOS ONE, followed 42 ies of urine which produced between 24 and 40 months of age with congenital Zika syndrome (CZS), as reported by the results of infection during pregnancy. General Chat Chat Lounge

Overall, these children had high grade cerebral palsy (Level 5, the highest in the gross motor function classification system; y; people needed a wheelchair to move in this state) and severe cognition, language why, motor. And nerve delays, including bilateral directional spasticity – are a disturbing feature of tension, stiffness, and failure to control muscle. However, by assessing the types of assessments, researchers also developed a heritage development. This difference can be seen, for example, in the variation in the degree of response to external stimuli of iation orn.

ies Urn underwent neurological and neurological developmental assessments using the Hammersmith Infant Neurological Examination (HINE), considered short and easy to apply, and the Baylinth Neuro Development Scale (Bayley-III). Improved scores were associated with neurological findings (HINE) and positively correlated with positive neurodevelopmental outcomes (Bayley-III). However, in the midst of the most severe cases, there were different scores, testifying to the difference.

In addition, it was found that a large ‘s head circumference (head circumference) was associated with a higher cognitive and motor level. In the sample, children had a head circumference of 31.9 cm and were smaller than 31.5 cm today, for boys and boys. This is the standard set by the World Health Organization (WHO) to counteract the suspected cases of microcephaly.

“Most research comp orts on utero-exposed Zika viruses and divides them into groups with and without microcephaly. They show, in the first case, a bad agonist with low neurological development and, in turn, to a lesser degree the risk of serious problems. Our study only includes children who have Zika syndrome and have been assessed for varying degrees of neurological symptoms to understand individual differences, not just as a group that can develop and follow a unique pathway. “Explains the researcher Juan Pablo Aguilar Tecuna, the first author of the article at the Institute for Public Health Federal University of Bahia (UFBA).

This work was supported by the Foundation for Research Support of the State of Sao Paulo (FAPESP) in the scope of thematic project “Detection of antigens and the development of serological diagnostic methods and vaccine strategies against the Zika virus”, whose responsible researchers Are Louis Carlos. De Souza Ferreira and Edison Luiz Doregan, both from the Institute of Biomedical Sciences at the University of Sao Paulo (USP). The presentation was with Professor Albert Coe, from Yale University, and Federico Costa, from the UFBA.

Aguilar Ticona says that some studies have used YES HINE to diagnose Z arn with Zika microcephaly. However, the first article to be published is one of the first to prove HINE scores in children’s sleep with the knowledge and motor development of them, an important tool for an early neurological examination.

According to him, even with today’s model, the study represents an opportunity to better understand microcephaly’s development after a few years. “After analyzing the results of the test and looking at the time in which the infants are exposed, it is possible to distinguish neuronal differences in the evolution of neurological evolution. One point we didn’t make at work, but it could have implications, is to analyze what factors in social factors, such as education and family, can also be fostered, “says Aguilar Tecuna.

An article published by the same group in July this year, in the journal PLOS Neglected Tropical Diseases, showed that low education and food insecurity are the most effective effects of social decision making on pregnant women. Be analyzed.

The work, also supported by FAPESP, includes data from 469 pregnant women, 61% of whom tested positive for the virus during the 2015-2016 outbreak in Salvador. In this invention, information was collected on demographic, socio-economic, and clinical characteristics, assessing Zika exposure through serological viral neutralization tests. The results help clarify risk factors that can be addressed to reduce the impact of infection on vulnerable populations through future interventions.

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Recently published surveys of children at the microcephaly outpatient clinic of Hern سانn Salvador Hospital Gerald Roberto Santos (HGRS), who were born at the height of the Zika epidemic between October 2015 and January 2016, and followed on site. Sweet.

At the time, Brazil was one of the countries with the highest number of cases of the disease. In part, the explanation is vector nail with the presence of a vector that transmits the virus, AIDS aseptic mosquito, which also transmits dengue. نشاني Signs of diseases are similar: fever, headache, redness in eyes, joint pain and scar in body.

Although Zika infection is usually infinite, research has shown a link between disease and progression to neurological syndromes like Guillain-Barré and meningitis in adults, and reproductive disorders such as microcephaly in newborns.

The prevalence of cases of infection and congenital syndrome, however, was not uniform across the country, with states in the Northern Territory centered. According to the Ministry of Health’s Bulletin, between 2015 and 2020, 3,423 ies were born in Brazil with Zika-linked congenital syndrome. Of those who were still living till last year (about 2,900), R56 and 56.4% received special care.

Following the study, the children were treated by a multidisciplinary team, including physiotherapists, speech therapists, nurses and therapists (including an eye specialist and neurologist). Information about the mother and about Arn was collected through interviews, medical records and clinical ations.

For HINE, 26 items were evaluated, including posters, movements, tone nails and cranial nerve reflexes. In children under 18 months of age, the ideal HINE score is 74 or greater for this section. In children Erin with neurodevelopmental disorder, a score of less than 40 is associated with severe motor impairment, a range in which most detected pneumonia.

In the case of the Bailey Scale, a urn was a study of cognition, (speech (expressive and responsive) and motor (sophisticated and overall)), and also tested visual function such as sensitivity to light, eye accuracy, stability, Object tracking, acuity and eye contact, plus social reactions to smiles and visual stimuli.

“In order to better understand the difference between them and to identify the early intervention that can mitigate the effects of the disease, it is important to first state that new diagnostic tools are currently available or their standard adjustments that are currently employed. Indicate differences and can be used for monitoring. And assessment of disease prevalence. Healthcare professionals need simple, practical and reliable tests to integrate long-term results for their patients, ”the researcher writes in the article.

Although the duration of the outbreak has already been completed five years ago, cases of micro-infection continue to be registered in Brazil due to Zika. Considering R2020 and 2020, 1,007 cases were reported, of which 35 were confirmed and 597 were under investigation until February this year, when the Ministry published the last Bulletin.

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